Facility Core 1: Molecular Biology


The Molecular Biology Facility Core (MB Core) provides services that include automated DNA isolation, genotyping, automated DNA sequencing, gene expression analysis,  protein analysis and technique training. The MB Core is located in the Department of Molecular Carcinogenesis at the University of Texas MD Anderson Science Park in Smithville, Texas.  The MB Core is directed by Jianjun Shen, PhD who has over 20 years of experience in the field of molecular biology and has been MB Core director since 1998.  This centralized facility core provides Center member access to:  state-of-the-art equipment, highly trained technical personnel, reduced service costs, standardized quality control measures, and in many cases provision of services that are outside of the expertise of the individual Center member. For additional information please view the Services and Price Structure documents to the right or contact Dr. Shen directly.
Now Available Next Generation Sequencing Capabilities
In November 2011, Dr. JianJun Shen, Director of the Molecular Biology Facility Core, was awarded a CPRIT Core Facility Support grant for nearly $6M to establish a Next Generation Sequencing (NGS) facility at Science Park and to support its operation for 5 years. The construction of core facility has been completed and the equipment has been acquired. The instrumentation includes:
1) an Illumina HiSeq2000 
2) an Illumina MiSeq
3) an Illumina cBot Cluster GenerationSystem
4) a primary computing server 
5) a secondary smaller server
6) Illumina and open source software 
7) a Covaris S220 for DNA shearing
8) a Beckman Coulter SPRI-TE: SPRIworks Fragment Library System I
9) an Agilent 2100 Bioanalyzer 
The NGS core is currently offering RNA-Seq services, and will be offering ChIP-Seq, exome resequencing, targeted resequencing, methylation sequencing and whole genome sequencing services shortly.
For the grant abstract visit the CPRIT site.
For more information on CPRIT awards to MD Andersonview the Press Release.